Status epilepticus enhances tonic GABA currents and depolarizes
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چکیده
*Authors contributed equally 8 Running title: Status epilepticus alters dentate basket cell tonic inhibition 9 Abstract 37 Temporal lobe epilepsy is associated with loss of interneurons and inhibitory dysfunction in the 38 dentate gyrus. While status epilepticus (SE) leads to changes in granule cell inhibition, whether 39 dentate basket cells critical for regulating granule cell feed-forward and feedback inhibition 40 express tonic GABA currents (I GABA) and undergo changes in inhibition following SE is not 41 known. We find that interneurons immunoreactive for parvalbumin in the hilar-subgranular 42 region express GABA A receptor (GABA A R) δ subunits, which are known to underlie tonic 43
منابع مشابه
Status epilepticus enhances tonic GABA currents and depolarizes GABA reversal potential in dentate fast-spiking basket cells.
Temporal lobe epilepsy is associated with loss of interneurons and inhibitory dysfunction in the dentate gyrus. While status epilepticus (SE) leads to changes in granule cell inhibition, whether dentate basket cells critical for regulating granule cell feedforward and feedback inhibition express tonic GABA currents (I(GABA)) and undergo changes in inhibition after SE is not known. We find that ...
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